![]() ![]() The hs-cTnI assay has a limit of detection of 1.1 to 1.9 ng/L and a 99th percentile of 26.2 ng/L. Further work is required to define species-specific reference intervals for cTnI. Troponin concentrations were subsequently measured by the hs-cTnI assay on an Architect platform and I-Stat TnI-Nx assay (Abbott Point of Care) on an I-Stat blood analyzer (Abbott Point of Care) on the same samples at the same time. In conclusion, the assessment of cTnI using the i-STAT®1 hand-held analyser shows promise as a humoral marker of cardiac pathology in mammalian species but not for avian and reptilian species. All avian and reptilian samples were below 0.00 µg/L even though overt cardiac pathology was noted in some of these animals. The majority of animals with concentrations of cTnI above 0.08 µg/L were subsequently shown to have pathology with potential cardiac involvement. The i-STAT cardiac troponin I (cTnI) test is an in vitro diagnostic test for the quantitative measurement of cardiac troponin I (cTnI) in whole blood or plasma. Concentrations of cTnI below, equal to and well above a suggested cut-off of 0.08 µg/L were observed in mammalian species. During routine health checks at the Zoological Society of London, 171 blood samples were collected from 36 different species (27 mammal, seven bird and two reptile) and were analysed for cTnI using the i-STAT®1 hand-held analyser. Performed at authorized locations by point of care operators. The secondary aim was to explore whether elevations in cTnI were related to underlying cardiac pathology. Abbott i-Stat - two-site enzyme-linked immunosorbent assay (ELISA) Test Usage. The primary aim of this feasibility study was to determine whether the i-STAT®1 hand-held analyser can be used to identify elevations of serum and plasma cTnI in a variety of non-domestic species. Recent advances in human and domestic animal medicine have shown cardiac troponin I (cTnI) to be the biomarker of choice for myocardial damage. i-STAT cTnI cartridges Product Usage: The i-STAT cTnl test is an in vitro diagnostic test for the quantitative measurement of cardiac troponin I in. ![]() However due to the wide range of species dealt with and their different sizes, few techniques have been validated. In the field of cardiology the diagnostic techniques used for domestic animals are also applied to exotic species. As heart damage increases, greater amounts of troponin are released in the blood. When heart muscles become damaged, troponin is sent into the bloodstream. Troponin isnt normally found in the blood. Troponin is a type of protein found in the muscles of your heart. One of the main challenges faced by veterinary surgeons in the field of zoo and wild animal medicine is the lack of published reference data and validated tests for non-domestic species. The new i-STAT 10-Minute Cardiac Troponin I (cTnI) Test cartridge (below) is designed to run with the companys portable analyzer and deliver test results in. A troponin test measures the level of troponin in your blood. International Primate Heart Project, Cardiff Metropolitan University St Georges University Hospitals NHS Foundation Trust Zoological Society of London and International Primate Heart Project, Cardiff Metropolitan University
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